轧制道次间插入冷却对特厚钢板组织与性能的影响

使用实验轧机旁冷却装置配合轧机进行轧制实验，研究轧制道次间不同冷却工艺对特厚钢板组织和性能的影响规律.研究结果表明:采用道次间冷却工艺可以在全厚度方向获得组织细化及强韧性提高效果，采用强冷道次间冷却实验钢1/4处晶粒尺寸可细化至10μm，强度为376MPa，-40℃冲击功为169J;心部晶粒尺寸可细化至15μm，强度为360MPa，-40℃冲击功为123J.本工艺可形成470μm厚表层细晶层，晶粒尺寸可细化至5μm;粗轧道次间插入冷却工艺轧制钢板强度和冲击韧性优于中间坯冷却工艺;随冷却强度增加，钢板内部组织明显细化且强度大幅提高.     

高新技术企业创新资金配置风险预警的FOA-SVM模型及实证

为了提高创新资金的运营效率和为企业创新活动提供有效支撑,按照高新技术企业创新资金配置的生态化要求,从资金的来源、使用、偿还、收益分配四个维度进行风险分析并构建风险预警指标,给出创新资金配置的生态目标,将支持向量机二分类问题扩展到多分类并与果蝇优化算法结合构建风险预警的FOA-SVM (fruit fly optimization algorithm and support vector machines)模型,确定警度和警限,选取117家医药制造企业2016年数据进行模型验证并与GA-SVM (genetic algorithm and support vector machines)模型进行比较分析,研究表明,FOA-SVM模型分类准确率高而且对于高风险的误判率低,可以实现对高新技术企业创新资金配置风险的分类预警,为优化创新资金配置、防范与控制创新资金配置风险提供依据.     

一种自适应步长的复合梯度加速优化算法

自适应步长加速(Adam)类算法由于其计算效率高、兼容性好的特点，成为近期相关领域的研究热点.针对Adam收敛速度慢的问题，本文基于当前梯度、预测梯度以及历史动量梯度，提出一种新型Adam类一阶优化算法——复合梯度下降法(C-Adam)，并对其收敛性进行了理论证明.与其他加速算法的区别之处在于，C-Adam将预测梯度与历史动量区别开，通过一次真实的梯度更新找到下一次迭代更精准的搜索方向.利用两组常用测试数据集及45钢静拉伸破坏实验的实验数据对所提算法进行验证，实验结果表明C-Adam与其他流行算法相比较具有更快的收敛速度及更小的训练损失.     

Prion protein cleavage fragments regulate adult neural stem cell quiescence through redox modulation of mitochondrial fission and SOD2 expression

Neurogenesis continues in the post-developmental brain throughout life. The ability to stimulate the production of new neurones requires both quiescent and actively proliferating pools of neural stem cells (NSCs). Actively proliferating NSCs ensure that neurogenic demand can be met, whilst the quiescent pool makes certain NSC reserves do not become depleted. The processes preserving the NSC quiescent pool are only just beginning to be defined. Herein, we identify a switch between NSC proliferation and quiescence through changing intracellular redox signalling. We show that N-terminal post-translational cleavage products of the prion protein (PrP) induce a quiescent state, halting NSC cellular growth, migration, and neurite outgrowth. Quiescence is initiated by the PrP cleavage products through reducing intracellular levels of reactive oxygen species. First, inhibition of redox signalling results in increased mitochondrial fission, which rapidly signals quiescence. Thereafter, quiescence is maintained through downstream increases in the expression and activity of superoxide dismutase-2 that reduces mitochondrial superoxide. We further observe that PrP is predominantly cleaved in quiescent NSCs indicating a homeostatic role for this cascade. Our findings provide new insight into the regulation of NSC quiescence, which potentially could influence brain health throughout adult life.     

互助担保:连带责任、互助保证金与成员努力程度

构建了针对现行互助担保模式的简单模型，分析了在互助担保中连带责任以及互助保证金对成员企业努力程度的影响.为了进一步激励成员企业的努力程度，提出增加监督惩罚机制和次序担保贷款机制，并通过建立动态激励模型验证了这些机制的有效性.研究结果如下:在现行的互助担保机制下，连带责任越大成员企业努力程度越低，且保证金越多成员企业努力程度越低，而引入监督惩罚机制以及次序贷款机制能够一定程度避免成员企业低努力程度行为的发生.     

复变函数论教学方法探讨

针对师范类院校复变函数论教学的现状,结合自身教学的实践心得体会,通过实例,分别从类比、逆否命题和反例等3个方面探讨了复变函数论的教学方法。     

A new twist to the No Miracles Argument for the success of science

J. D. Trout has recently developed a new defense of scientific realism, a new version of the No Miracles Argument. I critically evaluate Trout's novel defense of realism. I argue that Trout's argument for scientific realism and the related explanation for the success of science are self-defeating. In the process of arguing against the traditional realist strategies for explaining the success of science, he inadvertently undermines his own argument.